Microneedle patch technology

Microneedle drug delivery technology is a new minimally invasive method of delivering drugs on the skin. The microneedle patch acts on the skin, and the needle tip can penetrate the stratum corneum to achieve transdermal/intracutaneous controlled release of drugs. This technology combines the advantages of injection and transdermal administration, and can greatly expand the types of drugs administered through skin, such as proteins, peptides, vaccines, DNA of biological macromolecules, as well as strong hydrophilic and hydrophobic drugs. It can be administered independently and accurately, and its a platform technology for the development of new drug improvement formulations. Microneedle technology has been selected as one of the top ten emerging technologies by Scientific American in 2020, and these new technologies may bring revolutionary changes to industry, healthcare, and society!

Coating Microneedle Technology

The surface of the insoluble microneedle tip is coated with a layer of medication, and the microneedle can quickly release the medication when inserted into the skin, making it suitable for micro and precise quantitative administration.

Dissolving Microneedle Technology

Using water-soluble medicinal polymer excipients as the microneedle matrix, drugs/active ingredients are uniformly dispersed in the matrix material or needle tip matrix material to form microneedle patches. When the microneedle tip enters the skin, it can quickly dissolve and release drugs.

Swelling Microneedle Technology

The microneedle patch is insoluble in water, and the tip of the needle enters the skin to form a swelling gel. The drugs on the microneedle patch can enter the body along the drug delivery channel opened by the swelling gel to achieve drug release, and the tip after drug release can be completely removed from the skin. It is an improvement in transdermal drug delivery technology, suitable for high-dose transdermal drug delivery.

Team Achievements

Wang, B.; Zhang, S.; Cheng, A.; Yan, J.; Gao, Y. Soluble Polymer Microneedles Loaded with Interferon Alpha 1b for Treatment of Hyperplastic Scar. Polymers 2023, 15, 2621.

Wang, B., Liu, H., Zhang, S. et al. Aspirin microcrystals deposited on high-density microneedle tips for the preparation of soluble polymer microneedles. Drug Deliv. and Transl. Res. (2023).

Liu H, Wang B, Xing M, et al. Thermal stability of exenatide encapsulated in stratified dissolving microneedles during storage. Int J Pharm. 2023;636:122863.

Wang, B., Zhang, S., Yang, G., Zhou, Z., Xing, M., Liu, H., Cheng, A., Gao, Y., 2023. Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation. Asian Journal of Pharmaceutical Sciences 18(1): 100776.

Xing, M., Liu, H., Meng, F., Ma, Y., Zhang, S., Gao, Y., 2022. Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas. Polymers 14(21): 4475.

Xing, M., Zhang, S., Ma, Y., Chen, Y., Yang, G., Zhou, Z., Gao, Y., 2022. Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy. Journal of Drug Delivery Science and Technology 75: 103667.

Liu, H., Zhang, S., Zhou, Z., Xing, M., Gao, Y., 2022. Two-Layer Sustained-Release Microneedles Encapsulating Exenatide for Type 2 Diabetes Treatment. Pharmaceutics 14 (6): 1255.

Zhou, Z., Xing, M., Zhang, S., Yang, G., Gao, Y., 2022. Process optimization of Ca2+ cross-linked alginate-based swellable microneedles for enhanced transdermal permeability: More applicable to acidic drugs, International Journal of Pharmaceutics 168: 121669.

Zhou, Z., Zhang, S., Yang, G., Gao, Y., 2021. Enhanced delivery efficiency and sustained release of biopharmaceuticals by complexation-based gel encapsulated coated microneedles: rhIFN alpha-1b example. Asian Journal of Pharmaceutical Sciences 16(5): 612-622.

Wang, B., Zhang, S., Zhao, X, Lian, J., Gao, Y., 2021. Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles. Drug Delivery and Translational Research 12(4): 944-956.

Xing, M., Yang, Y., Zhang, S., Gao, Y., 2021. Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. European Journal of Pharmaceutical Sciences 165: 105935.

Xing, M., Wang, X., Zhao, L., Zhou, Z., Liu, H., Wang, B., Cheng, A., Zhang, S., Gao, Y., 2021. Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract. International Journal of Pharmaceutics 600, 120406.

Cheng, A., Sun, W., Xing, M., Zhang, S., Gao, Y., 2020. The hygroscopicity of polymer microneedles on the performance of dissolving behavior for transdermal delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-7.

He, M., Yang, G., Zhao, X., Zhang, S., Gao, Y., 2020. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release. Journal of Pharmaceutical Sciences 109, 1958-1966.

Zhao, X., Zhang, S., Yang, G., Zhou, Z., Gao, Y., 2020. Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles. Polymers 12.

Chen, Z., Han, B., Liao, L., Hu, X., Hu, Q., Gao, Y., Qiu, Y., 2020. Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis. Journal of Drug Delivery Science and Technology 55, 101487.

王雪, 赵小峪, 周泽荃, 邢梦真, 高云华, 赵立春, 张锁慧, 2020. 氨甲环酸在治疗黄褐斑领域中的应用进展. 药学研究, 348-354.

徐可, 杨国忠, 黄蓉, 曹泽明, 田丁阳, 陈云梦, 徐楠, 朱庆文, 高云华, 2020. 基于微机电系统技术的新型微针耳穴贴压治疗失眠疗效观察. 辽宁中医杂志 47, 173-175+224.

Liu, S., Zhang, S., Duan, Y., Niu, Y., Gu, H., Zhao, Z., Zhang, S., Yang, Y., Wang, X., Gao, Y., Yang, P., 2019. Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal enterotoxin challenge. Vaccine 37, 3810-3819.

He, M., Yang, G., Zhang, S., Zhao, X., Gao, Y., 2018. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery. Journal of Pharmaceutical Sciences 107, 1037-1045.

Yang, G., He, M., Zhang, S., Wu, M., Gao, Y., 2018. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron. Drug Development and Industrial Pharmacy 44, 808-816.

段雪艳, 马佳男, 宁美英, 高云华, 2018. 孕二烯酮缓释避孕微针含量及其有关物质的测定方法研究. 中国计划生育学杂志 26, 15-18.


宋思雨, 李中梁, 高云华, 余俊杰, 南楠, 王瑄, 袁春晓, 王向朝, 2018. 用于微针经皮给药成像的扫频OCT系统. 中国激光 45, 209-216.

李明辉, 王希良, 邱玉琴, 杨国忠, 刘思齐, 邢丽, 张良艳, 周娅, 杨鹏辉, 高云华, 2017. 流感病毒灭活疫苗可溶性微针制备及评价. 免疫学杂志 033, 477-481,487.

Chen, J., Qiu, Y., Zhang, S., Gao, Y., 2016. Dissolving microneedle-based intradermal delivery of interferon-α-2b. Drug Development and Industrial Pharmacy 42, 890-896.

Qiu, Y., Guo, L., Zhang, S., Xu, B., Gao, Y., Hu, Y., Hou, J., Bai, B., Shen, H., Mao, P., 2016a. DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN. Drug Delivery 23, 2391-2398.

Qiu, Y., Li, C., Zhang, S., Yang, G., He, M., Gao, Y., 2016b. Systemic delivery of artemether by dissolving microneedles. International Journal of Pharmaceutics 508, 1-9.

邱玉琴, 李春, 张锁慧, 杨国忠, 贺美琳, 高云华, 2016a. 蒿甲醚可溶解微针透皮贴片的制备和评价. 今日药学, 532-537.

邱玉琴, 薛建强, 高云华, 2016b. 中国微针技术相关专利综述与分析. 今日药学 026, 672-675.

Qiu, Y., Guo, L., Mao, P., Gao, Y., 2015. Dissolving Microneedle Arrays for Intradermal Immunization of Hepatitis B Virus DNA Vaccine. Procedia in Vaccinology 9, 24-30.

Chen, J., Qiu, Y., Zhang, S., Yang, G., Gao, Y., 2015. Controllable coating of microneedles for transdermal drug delivery. Drug Development and Industrial Pharmacy 41, 415-422.

张锁慧, 邱玉琴, 杨国忠, 高云华, 2014. 明胶作为左旋肉碱贴膏剂载体的体外经皮渗透性评价. 明胶科学与技术 034, 181-186.

Qiu, Y., Gao, Y., Zhang, S., Guo, L., Chen, J., Xu, B., 2013. Immunological effects of microneedle-mediated insulin delivery: Preliminary rat studies. International Journal of Pharmaceutics 444, 103-105.

Chen, J., Lei, G., Qiu, Y., Zhang, S., Gao, Y., 2013. Fabrication of biodegradable polymer microneedles for transdermal drug delivery applications. Nanotechnology and Precision Engineering 11, 402-409.

Guo, L., Chen, J., Qiu, Y., Zhang, S., Xu, B., Gao, Y., 2013. Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant. International Journal of Pharmaceutics 447, 22-30.

陈健敏, 郭雷, 邱玉琴, 张锁慧, 高云华, 2013. 可生物降解高分子微针的制作及透皮应用. 纳米技术与精密工程 11, 402-409.

张锁慧, 邱玉琴, 高云华, 2013. 微针辅助左旋肉碱水凝胶制剂体内外经皮渗透性评价. 中国新药杂志, 2309-2313.

Qin, G., Gao, Y., Wu, Y., Zhang, S., Qiu, Y., Li, F., Xu, B., 2012. Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomedicine: Nanotechnology, Biology and Medicine 8, 221-227.

Zhang, S., Qin, G., Wu, Y., Gao, Y., Qiu, Y., Li, F., Xu, B., 2011. Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats. Pharmaceutical Research 28, 117-123.

Wu, Y., Gao, Y., Qin, G., Zhang, S., Qiu, Y., Li, F., Xu, B., 2010. Sustained release of insulin through skin by intradermal microdelivery system. Biomedical Microdevices 12, 665-671.

Qiu, Y., Gao, Y., Hu, K., Li, F., 2008. Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes. Journal of Controlled Release 129, 144-150.

Wu, Y., Qiu, Y., Zhang, S., Qin, G., Gao, Y., 2008. Microneedle-based drug delivery: studies on delivery parameters and biocompatibility. Biomedical Microdevices 10, 601-610.

李晓光, 赵荣生, 秦泽莲, 高云华, 张洁, 翟所迪, 徐百, 2008. 无痛微针透皮贴片对局部应用利多卡因的促渗作用. 中国新药杂志 017, 597-601.

Xie, Y., Xu, B., Gao, Y., 2005. Controlled transdermal delivery of model drug compounds by MEMS microneedle array. Nanomedicine: Nanotechnology, Biology and Medicine 1, 184-190.

Li, C., Wang, Y., Gao, Y., Guo, X.Y., Gu, Z., 2005. Magnetically actuated micromixing on an array-pattern microfluidic chip for immunoassay of human thyrotropin. Journal of Nanoscience and Nanotechnology 5, 1297-1300.

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