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微针贴剂技术----创新制剂研发平台技术
微针给药技术是一种新型的以微创方式在皮肤上传递药物的方法, 微针贴作用于皮肤,针尖能够刺入角质层,实现透皮/皮内控释药物释放。 该技术结合了注射给药和透皮给药的优势,能够大幅度拓展经皮给药的药物种类, 如生物大分子的蛋白、多肽、疫苗、DNA以及强亲水性药物和强疏水性药物,可以自主、精确给药, 是新药改良制剂开发的平台技术。微针技术入选《科学美国人》2020年十大新兴技术, 这些新技术有可能会给工业、医疗保健和社会带来革命性的变化!
不溶于水的微针针尖表面包衣一层药物,微针扎入皮内能快速释放药物,适用于微量、精准定量给药。
包衣微针技术
以水溶性的药用高分子辅料为微针基质, 将药物/活性成分均匀分散于基质材料中或者针尖的基质材料中形成微针贴片, 当微针针尖进入皮内时,能够快速溶解并释放药物。
溶解微针技术
微针贴片不溶于水,针尖进入皮内后形成溶胀凝胶, 微针贴片上面的药物能够沿着溶胀凝胶打开的给药通道进入体内,实现药物释放, 释药后的针尖能够被完整移出皮内。是透皮给药技术的改进,适用于大剂量透皮给药。
溶胀微针技术
团队成果

Xing, M., Wang, X., Zhao, L., Zhou, Z., Liu, H., Wang, B., Cheng, A., Zhang, S., Gao, Y., 2021. Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract. International Journal of Pharmaceutics 600, 120406.


Cheng, A., Sun, W., Xing, M., Zhang, S., Gao, Y., 2020. The hygroscopicity of polymer microneedles on the performance of dissolving behavior for transdermal delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-7.

He, M., Yang, G., Zhao, X., Zhang, S., Gao, Y., 2020. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release. Journal of Pharmaceutical Sciences 109, 1958-1966.


Zhao, X., Zhang, S., Yang, G., Zhou, Z., Gao, Y., 2020. Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles. Polymers 12.

Chen, Z., Han, B., Liao, L., Hu, X., Hu, Q., Gao, Y., Qiu, Y., 2020. Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis. Journal of Drug Delivery Science and Technology 55, 101487.


王雪, 赵小峪, 周泽荃, 邢梦真, 高云华, 赵立春, 张锁慧, 2020. 氨甲环酸在治疗黄褐斑领域中的应用进展. 药学研究, 348-354.


徐可, 杨国忠, 黄蓉, 曹泽明, 田丁阳, 陈云梦, 徐楠, 朱庆文, 高云华, 2020. 基于微机电系统技术的新型微针耳穴贴压治疗失眠疗效观察. 辽宁中医杂志 47, 173-175+224.


Liu, S., Zhang, S., Duan, Y., Niu, Y., Gu, H., Zhao, Z., Zhang, S., Yang, Y., Wang, X., Gao, Y., Yang, P., 2019. Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal enterotoxin challenge. Vaccine 37, 3810-3819.


He, M., Yang, G., Zhang, S., Zhao, X., Gao, Y., 2018. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery. Journal of Pharmaceutical Sciences 107, 1037-1045.


Yang, G., He, M., Zhang, S., Wu, M., Gao, Y., 2018. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron. Drug Development and Industrial Pharmacy 44, 808-816.


段雪艳, 马佳男, 宁美英, 高云华, 2018. 孕二烯酮缓释避孕微针含量及其有关物质的测定方法研究. 中国计划生育学杂志 26, 15-18.


刘思齐,杨国忠,李明辉,段跃强,牛燕,王希良,杨英,高云华,杨鹏辉.2018.重组金黄色葡萄球菌肠毒素B蛋白可溶性微针制备及免疫效果研究,免疫学杂志.

宋思雨, 李中梁, 高云华, 余俊杰, 南楠, 王瑄, 袁春晓, 王向朝, 2018. 用于微针经皮给药成像的扫频OCT系统. 中国激光 45, 209-216.


李明辉, 王希良, 邱玉琴, 杨国忠, 刘思齐, 邢丽, 张良艳, 周娅, 杨鹏辉, 高云华, 2017. 流感病毒灭活疫苗可溶性微针制备及评价. 免疫学杂志 033, 477-481,487.


Chen, J., Qiu, Y., Zhang, S., Gao, Y., 2016. Dissolving microneedle-based intradermal delivery of interferon-α-2b. Drug Development and Industrial Pharmacy 42, 890-896.


Qiu, Y., Guo, L., Zhang, S., Xu, B., Gao, Y., Hu, Y., Hou, J., Bai, B., Shen, H., Mao, P., 2016a. DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN. Drug Delivery 23, 2391-2398.


Qiu, Y., Li, C., Zhang, S., Yang, G., He, M., Gao, Y., 2016b. Systemic delivery of artemether by dissolving microneedles. International Journal of Pharmaceutics 508, 1-9.


邱玉琴, 李春, 张锁慧, 杨国忠, 贺美琳, 高云华, 2016a. 蒿甲醚可溶解微针透皮贴片的制备和评价. 今日药学, 532-537.


邱玉琴, 薛建强, 高云华, 2016b. 中国微针技术相关专利综述与分析. 今日药学 026, 672-675.


Qiu, Y., Guo, L., Mao, P., Gao, Y., 2015. Dissolving Microneedle Arrays for Intradermal Immunization of Hepatitis B Virus DNA Vaccine. Procedia in Vaccinology 9, 24-30.


Chen, J., Qiu, Y., Zhang, S., Yang, G., Gao, Y., 2015. Controllable coating of microneedles for transdermal drug delivery. Drug Development and Industrial Pharmacy 41, 415-422.


张锁慧, 邱玉琴, 杨国忠, 高云华, 2014. 明胶作为左旋肉碱贴膏剂载体的体外经皮渗透性评价. 明胶科学与技术 034, 181-186.


Qiu, Y., Gao, Y., Zhang, S., Guo, L., Chen, J., Xu, B., 2013. Immunological effects of microneedle-mediated insulin delivery: Preliminary rat studies. International Journal of Pharmaceutics 444, 103-105.


Chen, J., Lei, G., Qiu, Y., Zhang, S., Gao, Y., 2013. Fabrication of biodegradable polymer microneedles for transdermal drug delivery applications. Nanotechnology and Precision Engineering 11, 402-409.


Guo, L., Chen, J., Qiu, Y., Zhang, S., Xu, B., Gao, Y., 2013. Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant. International Journal of Pharmaceutics 447, 22-30.


陈健敏, 郭雷, 邱玉琴, 张锁慧, 高云华, 2013. 可生物降解高分子微针的制作及透皮应用. 纳米技术与精密工程 11, 402-409.


张锁慧, 邱玉琴, 高云华, 2013. 微针辅助左旋肉碱水凝胶制剂体内外经皮渗透性评价. 中国新药杂志, 2309-2313.


Qin, G., Gao, Y., Wu, Y., Zhang, S., Qiu, Y., Li, F., Xu, B., 2012. Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomedicine: Nanotechnology, Biology and Medicine 8, 221-227.


Zhang, S., Qin, G., Wu, Y., Gao, Y., Qiu, Y., Li, F., Xu, B., 2011. Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats. Pharmaceutical Research 28, 117-123.


Wu, Y., Gao, Y., Qin, G., Zhang, S., Qiu, Y., Li, F., Xu, B., 2010. Sustained release of insulin through skin by intradermal microdelivery system. Biomedical Microdevices 12, 665-671.


Qiu, Y., Gao, Y., Hu, K., Li, F., 2008. Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes. Journal of Controlled Release 129, 144-150.


Wu, Y., Qiu, Y., Zhang, S., Qin, G., Gao, Y., 2008. Microneedle-based drug delivery: studies on delivery parameters and biocompatibility. Biomedical Microdevices 10, 601-610.


李晓光, 赵荣生, 秦泽莲, 高云华, 张洁, 翟所迪, 徐百, 2008. 无痛微针透皮贴片对局部应用利多卡因的促渗作用. 中国新药杂志 017, 597-601.


Xie, Y., Xu, B., Gao, Y., 2005. Controlled transdermal delivery of model drug compounds by MEMS microneedle array. Nanomedicine: Nanotechnology, Biology and Medicine 1, 184-190.


Li, C., Wang, Y., Gao, Y., Guo, X.Y., Gu, Z., 2005. Magnetically actuated micromixing on an array-pattern microfluidic chip for immunoassay of human thyrotropin. Journal of Nanoscience and Nanotechnology 5, 1297-1300.


赵红, 高云华, 2006. 微针——开启透皮给药的又一扇门. 中国医药报, p. 007.


高云华, 2005. 微针透皮给药系统研究进展. 中医外治杂志 14, 3-7.


中科微针专注于聚合物微针透皮给药平台
技术的研究及其在药品、医疗器械及大健
康领域的创新及产业化工作。
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