微针贴剂技术----创新制剂研发平台技术
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微针药物递送作为新型经皮递送技术,是一种主动皮肤渗透增强技术。微针呈针状结构,其长度通常为几百微米,将其作用皮肤后,可以突破角质层皮肤屏障,仅以微创方式穿透表皮,在皮肤上形成微米大小的孔,以增强药物传递,而不会损伤真皮中的神经元,从而最大限度地减少与透皮给药相关的疼痛,显示出改善的皮肤渗透性并增强透皮给药。这可以克服传统注射给患者带来的不适感,针头恐惧感和副作用,同时具有无痛无创的特点,给药简单方便,提高患者的依从性。随着微针制备技术的提升,微针技术在医药领域取得了显著的成果。微针技术的发展有利于实现温度敏感型药物的脱冷链运输及储存,可大幅降低运输成本。

微针药物递送技术结合了注射给药和透皮给药的优势,能够大幅度拓展经皮给药的药物种类,如生物大分子的蛋白、多肽、疫苗、DNA以及强亲水性药物和强疏水性药物。



包衣微针技术
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不溶于水的微针针尖表面包衣一层药物,微针扎入皮内能快速释放药物,适用于微量、精准定量给药。


溶解微针技术
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以水溶性的药用高分子辅料为微针基质, 将药物/活性成分均匀分散于基质材料中或者针尖的基质材料中形成微针贴片, 当微针针尖进入皮内时,能够快速溶解并释放药物。


溶胀微针技术
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微针贴片不溶于水,针尖进入皮内后形成溶胀凝胶, 微针贴片上面的药物能够沿着溶胀凝胶打开的给药通道进入体内,实现药物释放, 释药后的针尖能够被完整移出皮内。是透皮给药技术的改进,适用于大剂量透皮给药。


团队成果

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Chen, Z., Han, B., Liao, L., Hu, X., Hu, Q., Gao, Y., Qiu, Y., 2020. Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis. Journal of Drug Delivery Science and Technology 55, 101487.

王雪, 赵小峪, 周泽荃, 邢梦真, 高云华, 赵立春, 张锁慧, 2020. 氨甲环酸在治疗黄褐斑领域中的应用进展. 药学研究, 348-354.

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Liu, S., Zhang, S., Duan, Y., Niu, Y., Gu, H., Zhao, Z., Zhang, S., Yang, Y., Wang, X., Gao, Y., Yang, P., 2019. Transcutaneous immunization of recombinant Staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal enterotoxin challenge. Vaccine 37, 3810-3819.

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Yang, G., He, M., Zhang, S., Wu, M., Gao, Y., 2018. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron. Drug Development and Industrial Pharmacy 44, 808-816.

段雪艳, 马佳男, 宁美英, 高云华, 2018. 孕二烯酮缓释避孕微针含量及其有关物质的测定方法研究. 中国计划生育学杂志 26, 15-18.

刘思齐,杨国忠,李明辉,段跃强,牛燕,王希良,杨英,高云华,杨鹏辉.2018.重组金黄色葡萄球菌肠毒素B蛋白可溶性微针制备及免疫效果研究,免疫学杂志.

宋思雨, 李中梁, 高云华, 余俊杰, 南楠, 王瑄, 袁春晓, 王向朝, 2018. 用于微针经皮给药成像的扫频OCT系统. 中国激光 45, 209-216.

李明辉, 王希良, 邱玉琴, 杨国忠, 刘思齐, 邢丽, 张良艳, 周娅, 杨鹏辉, 高云华, 2017. 流感病毒灭活疫苗可溶性微针制备及评价. 免疫学杂志 033, 477-481,487.

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Qiu, Y., Guo, L., Zhang, S., Xu, B., Gao, Y., Hu, Y., Hou, J., Bai, B., Shen, H., Mao, P., 2016a. DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN. Drug Delivery 23, 2391-2398.

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Chen, J., Qiu, Y., Zhang, S., Yang, G., Gao, Y., 2015. Controllable coating of microneedles for transdermal drug delivery. Drug Development and Industrial Pharmacy 41, 415-422.

张锁慧, 邱玉琴, 杨国忠, 高云华, 2014. 明胶作为左旋肉碱贴膏剂载体的体外经皮渗透性评价. 明胶科学与技术 034, 181-186.

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Qiu, Y., Gao, Y., Hu, K., Li, F., 2008. Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes. Journal of Controlled Release 129, 144-150.

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